@ UCSF Institute for Neurodegenerative Diseases
6. Trans-channel fluorescence learning improves a high content screen for Alzheimer’s disease therapeutics Nature Machine Intelligence 2022 ,4, 583 Wong DR, Conrad J, Johnson N, Lee JC, Ayers JA, Lee J, Laeremans A, Prusiner SB, Bandyopadhyay S, Paras NA, Butte AJ, Keiser MJ
5. Water-Soluble Iridium Photoredox Catalyst for the Trifluoromethylation of Biomolecule Substrates in Phosphate Buffered Saline Solvent Org. Lett. 2021, 23, 10, 3823 Terrence-Thang H. Nguyen, Connor J. O’Brien, Minh L. N. Tran, Steven H. Olson, Nicholas S. Settineri, Stanley B. Prusiner, Nick A. Paras, Jay Conrad
4. Silver Benzoate Facilitates the Copper-Catalyzed C–N Coupling of Iodoazoles with Aromatic Nitrogen Heterocycles ACS Omega 2021, 6, 14, 9804 Cedric Lozano, Cristian Ramirez, Ny Sin, Hélène M.-F. Viart, Stanley B. Prusiner, Nick A. Paras, Jay Conrad
3. Selectivity in the Addition of Electron-Deficient Radicals to the C2 Position of Indoles EJOC 2020, 36, 5828 Dr. Yi Li, Dr. Roy J. Vaz, Dr. Steven H. Olson, Dr. Mark Munson, Dr. Nick A. Paras, Prof. Dr. Jay Conrad
2. Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity ACS Med. Chem. Lett. 2020, 11, 2, 127 Jean-Marc M. Grandjean, Alexander Y. Jiu, John W. West, Atsushi Aoyagi, Daniel G. Droege, Manuel Elepano, Makoto Hirasawa, Masakazu Hirouchi, Ryo Murakami, Joanne Lee, Koji Sasaki, Shimpei Hirano, Takao Ohyama, Benjamin C. Tang, Roy J. Vaz, Masahiro Inoue, Steven H. Olson, Stanley B. Prusiner, Jay Conrad*, Nick A. Paras
1. Photoredox Cyanomethylation of Indoles: Catalyst Modification and Mechanism J. Org. Chem. 2018, 83, 16, 8926 Connor J. O’Brien, Daniel G. Droege, Alexander Y. Jiu, Shivaani S. Gandhi, Nick A. Paras, Steven H. Olson, Jay Conrad
Postdoctoral Work, MacMillan Lab, Princeton University
5. Enantioselective a-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from bCyanoaldehydes Angew. Chem. Int. Ed. 2015, 54, 9668 Eric R. Welin, Alexander A. Warkentin, Jay C. Conrad, and David W. C. MacMillan
4. A General and Enantioselective Approach to Pentoses: A Rapid Synthesis of PSI-6130, the Nucleoside Core of Sofosbuvir J. Am. Chem. Soc. 2014, 136, 16, 5900 Manuel Peifer, Raphaelle Berger, Valerie W. Shurtleff, Jay C. Conrad, and David W. C. MacMillan
3. Enantioselective Organocatalytic R-Fluorination of Cyclic Ketones J. Am. Chem. Soc. 2011, 133, 6, 1738 Piotr Kwiatkowski, Teresa D. Beeson, Jay C. Conrad, and David W. C. MacMillan
2. Mechanistic Complexity in Organo–SOMO Activation Angew. Chem. Int. Ed., 49, 6106-6110 J. J. Devery III, J. C. Conrad, D. W. C. MacMillan, R. A. Flowers II
1. Enantioselective α-Arylation of Aldehydes via Organo-SOMO Catalysis. An Ortho-Selective Arylation Reaction Based on an Open-Shell Pathway J. Am. Chem. Soc. 2009, 131, 33, 11640 Jay C. Conrad, Jongrock Kong, Brian N. Laforteza, and David W. C. MacMillan
Conrad Lab 